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In agreement with these data, inactivation of this pathway in astrocytes reduces MAFG signaling, methylation of target genes and expression of proinflammatory pathways resulting in clinical improvement in EAE (130)

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Acknowledgment The work in this study was supported by the Natural Science Foundation of China (grants 30971188, 81273279, 81302560, and 81373201)

The permeability study demonstrated enhanced BBB (in vitro model) permeability mediated by lactoferrin receptor-targeted transcytosis, showing a 2.7-fold increase in fluorescence intensity for lactoferrin-conjugated nanoparticles compared to non-functionalized ones

As finasteride blocks the conversion process of testosterone to dihydrotestosterone, it has also been utilized to treat AGA in patients